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Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof
专利权人:
Boehringer Ingelheim Animal Health USA Inc.
发明人:
Cady, Susan,Cheifetz, Peter,Meng, Charles,Le Hir De Fallois, Lois,Galeska, Izabela
申请号:
NZ74585917
公开号:
NZ745859A
申请日:
2017.02.24
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
There is a need to develop alternative long-acting injectable composition comprising an isoxazoline compound. Accordingly, the present disclosure provides a long-acting injectable composition, comprising at least one parasiticidal isoxazoline active agent of formula (Ic), or a pharmaceutically acceptable salt thereof, wherein X1, X2 and X3 are defined herein, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This disclosure also provides isoxazoline active agents with long-lasting efficacy against ectoparasites. This disclosure also provides for methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering isoxazoline compounds and long-acting injectable compositions of the disclosure to the animal in need thereof.
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