The present disclosure relates to a therapeutic agent for use in a method for modulating the function and/or growth of a thymus in a subject, wherein the therapeutic agent comprises an HER2 or HER1 pathway antagonist or agonist, and/or a CCR/CCL5 antagonist the method involving administering the therapeutic agent to the subject. Also disclosed herein is a therapeutic agent for use in a method for treating a disorder in a subject, the disorder selected from systemic autoimmunity, peripheral autoimmunity and Systemic Lupus Erythematosus,
