EPITOPES PEPTIDIQUES IDENTIFIES PAR DES LYMPHOCYTES T AUXILIAIRES STIMULANT LA MALADIE

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专利权人:

ZYCOS INC.;KING'S COLLEGE LONDON

发明人:

PEAKMAN, MARK,CHICZ, ROMAN M.

申请号：

CA2370763

公开号：

CA2370763C

申请日:

2000.04.20

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The invention provides methods for identifying peptide epitopes that activateCD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmunediseases, susceptibility to which is determined by expression of particularclass II MHC genes. The invention includes peptides derived from the IA-2polypeptide by such a method, altered peptide ligands, and methods of therapyinvolving the use of altered peptide ligands.

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