A novel herbal formulation for the prevention and management of diabetes mellitus and its significance in the prevention of diabetic micro-vascular complications. A novel herbal formulation for the prevention of endothelial dysfunction Diabetes Mellitus and Diabetic Micro-Vascular complications comprising: Salacia chinensis and at least one other active constituent selected from Coccinia indica and Hippophae rhamnoides and optionally additives in trace amounts.