Disclosed are hydrogels polymerized with a free radical scavenger, for example a spin trap. The hydrogels are biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) spin trap end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the free radical scavenging aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.揭示以自由基清除劑例如自旋捕集劑聚合化之水凝膠。該水凝膠為生物可降解性及永久性、經設計可植入哺乳動物體內且意在阻斷或緩和組織沾黏之形成。本發明之水凝膠的特徵在於包含四種結構元件:a)界定整體聚合物形態之聚合物骨架,b)鍵聯基,c)側鏈,及d)自旋捕集劑端基。該各種結構元件之疏水性係經選擇以降低組織沾黏及提高端基之自由基清除方面。這些聚合物之形態典型地具有高分子量且具有助長纏結的形狀。可用的結構包括分枝鏈(梳狀或刷狀)、及樹狀形態。100‧‧‧凝膠聚合物102‧‧‧聚合物骨架104‧‧‧鍵聯基106‧‧‧側鏈108‧‧‧自由基清除性端基114‧‧‧橋116‧‧‧骨架的末端120‧‧‧側掛側鏈122‧‧‧自由基清除性基團124‧‧‧夾在兩個鍵聯基之間
