597680 Disclosed is pharmaceutical composition for suppressing pain in joint disorders, said composition comprising a pharmaceutically allowable carrier and hyaluronic acid cross-linked by means of cyclizing a double bond of the cinnamic acid portion of a partially amidated hyaluronic acid represented by general formula 1, [Ar-CH=CH-COO-(CH2)n-NH-]m-HA (wherein Ar represents a phenyl group that may have substituent groups, n represents 2 or 3, HA represents a carboxyl residue of hyaluronic acid, m represents the proportion of amidated carboxyl groups out of all of the carboxyl groups of hyaluronic acid, and m is 3- 50% of all of the carboxyl groups), forming a cyclobutane ring wherein a single-dose comprises hyaluronic acid in a weight of 25 mg to 35 mg, or wherein a content of the hyaluronic acid is 1.0% w/v relative to a total of a product and a single-dose is 2 mL to 3 mL. The pharmaceutical composition is an intra-articularly administered formulation that, after administration, has a rapid analgesic effect, and unlike the conventional plurality of administrations, with only one administration, sustains an extremely long-term effect on human joint disorders
