ALESSI, THOMAS R.,MERCER, RYAN D.,ROHLOFF, CATHERINE M.,YANG, BING
申请号：
CA2738715
公开号：
CA2738715C
申请日:
2009.10.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Highly concentrated drug particle formulations are described, wherein the drugcomprises between about 25 wt%and 80 wt% of the particle formulation. The particle formulations of thepresent invention comprise, for example, macro-molecules,such as proteins and/or small molecules (such as steroid hormones). Theparticle formulation typically further includesone or more additional component, for example, one or more stabilizer (e.g.,carbohydrates, antioxidants, amino acids, andbuffers). Such concentrated particle formulations can be combined with asuspension vehicle to form suspension formulations.The suspension formulation comprises (i) a non-aqueous, single-phase vehicle,comprising one or more polymer and one or moreone solvent, wherein the vehicle exhibits viscous fluid characteristics, and(ii) a highly concentrated drug particle formulation. Devicesfor delivering the suspension formulations and methods of use are alsodescribed. The present invention provides needed improvementsin drug formulation and delivery to improve patient compliance and expand drugavailability.
