This invention describes of a means of stabilizing lipophilic drugs for long-term storage by incorporating them into a “thermally stabilized nanoemulsion” that has a phase transition temperature that is at or below the body temperature of 37 C and above a storage temperature of 4-8 C. One or more lipid soluble drugs are incorporated into the nanoemulsion at an elevated temperature above the phase transition temperature of the nanoemulsion and then stabilized for extended storage by lowering the temperature to below its phase transition temperature. This causes the nanoemulsion to transform into solid lipid nanospheres entrapping the drug within the solid lipid matrix. Upon rewarming the lipid nanospheres they will reconvert to an oil-in-water nanoemulsion suitable for administration to the patient in need. This invention further discloses disease targeting thermally stabilized nanoemulsions utilizing targeting agents such as antibodies, aptamers, binding peptides, hormones, cytokines and the like, attached to the exterior of the nanodroplets comprising the nanoemulsion.
