MACDONALD LYNN,STEVENS SEAN,GURER CAGAN,MURPHY ANDREW J.,HOSIAWA KAROLINA A.
申请号：
NZ60575111
公开号：
NZ605751A
申请日:
2011.06.22
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a mouse comprising an endogenous &lambda； (lambda) light chain allele comprising an unrearranged human V&lambda； and an unrearranged human J&lambda； gene segment, where the mouse comprises a deletion in a first V&lambda；-J&lambda；-C&lambda； gene cluster of the endogenous mouse &lambda； light chain allele and replacement, in whole or in part, of the V&lambda；-J&lambda； gene segments of a second gene cluster of the allele with the human V&lambda； and J&lambda； gene segments which are operably linked to a mouse C&lambda； constant region gene so the mouse expresses a light chain comprising a human V&lambda； domain and a mouse C&lambda； domain. Also disclosed is a method for making an antibody in said mouse.
