The present invention relates to compounds of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing them, methods for their preparation, and their therapeutic use in promoting the application of moisture to mucosal surfaces. And treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.本発明は、式の化合物:又は薬学的に許容されるその塩、並びにそれらを含む組成物、それらを調製するための方法、粘膜表面への水分の付与の促進におけるそれらの治療的な使用方法、並びに慢性閉塞性肺疾患(COPD)、喘息、気管支拡張症、急性及び慢性気管支炎、嚢胞性線維症、気腫、及び肺炎を含む疾患の治療に関する。
