Sposób wytwarzania stałej, doustnej kompozycji farmaceutycznej zawierającej 5-chloro-N({(5S)-2-okso-3-[4-(3-okso-4-morfolinylo)fenylo]-1,3-oksazolidyn-5-ylo}mety-lo)-2-tiofenokarboksyamid

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH

发明人:

BENKE, KLAUS,BENKE KLAUS

申请号：

PL04797879

公开号：

PL1689370T5

申请日:

2004.11.13

申请国别(地区):

PL

年份:

2017

代理人:

摘要：

Production of solid, orally administered pharmaceutical compositions (A) containing 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)-phenyl)-1,3-oxazolidin-5-yl)-methyl)-2-thiophene-carboxamide (I) in hydrophilized form comprises: (a) preparing granules containing (I) in hydrophilized form by wet granulation； and (b) converting the granules, optionally with suitable additives, into (A). Independent claims are included for: (1) the compositions (A) obtained by the process； and (2) solid, orally administered pharmaceutical compositions (A') containing (I) in hydrophilized form in general. ACTIVITY : Thrombolytic； Anticoagulant； Cardiant； Antianginal； Vasotropic； Cerebroprotective. MECHANISM OF ACTION : Coagulation factor Xa inhibitor.

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