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HYDROXYPROPYLCELLULOSE FAIBLEMENT SUBSTITUÉE, SON PROCÉDÉ DE PRODUCTION ET PRÉPARATION SOLIDE
专利权人:
Ltd.;Shin-Etsu Chemical Co.
发明人:
申请号:
EP17195313.6
公开号:
EP3308776A1
申请日:
2017.10.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
There are provided low-substituted hydroxypropyl cellulose (L-HPC) having good compressibility and capping-prevention performance, and others. Specifically, provided are L-HPC having a hydroxypropoxy content of 5 to 16% by weight, a volume fraction of long fibrous particles of 20 to 40% and a volume fraction of short fibrous particles of 26 to 60% with the proviso that the latter is greater than the former; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps of: bringing powdery pulp having a length-weighted mean width of 10 to 25 µm into contact with an alkali metal hydroxide solution, reacting the alkali cellulose with propylene oxide, and neutralizing the alkali metal hydroxide present in the reaction product with an acid to precipitate crude low-substituted hydroxypropyl cellulose in the absence of a step of dissolving a portion or all of the reaction product.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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