Meinolf Brackhagen,Nicholas S. Grasman,Yongfu Li,David M. Meunier,Oliver Petermann,Matthias Sprehe
申请号:
US14420985
公开号:
US09745387B2
申请日:
2013.08.15
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A partially cross-linked esterified cellulose ether having A) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>;100 k)−Wf(>;100 k)XL]/Wf(>;100 k)XL is at least 0.20, wherein Wf(>;100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>;100 k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms.