HAE JIN KIM,JE WOOK LEE,YOUNG JOON KWON,EUN JOUNG MOON
申请号：
IN2682/MUMNP/2012
公开号：
IN2012MN02682A
申请日:
2012.12.03
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp X2 represents His Lys or Arg X3 represents Asp or Glu with Glu Asp Leu His Lys and Arg being respectively glutamic acid aspartic acid leucine histidine lysine and arginine or a pharmaceutically acceptable salt thereof a composition for the treatment or prevention of at least one selected from cartilage damage and arthritis containing the same peptide or a pharmaceutically acceptable salt thereof as an active ingredient and a composition containing the same peptide or a pharmaceutically acceptable salt thereof and TGFß1. The above-mentioned peptide or a pharmaceutically acceptable salt thereof is effective for the treatment and/or prevention of cartilage damage and/or arthritis and is capable of exhibiting effects of the regeneration of cartilage tissue the inhibition of the expression of cartilage tissue matrix degrading enzyme and/or the inhibition of cartilage tissue ossification.
