A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.本發明係關於一種醫藥膠囊,其包含內部囊封有ABT-263或其醫藥學上可接受之鹽於實質上非乙醇性載劑中之液體溶液的外殼,該載劑包含以下醫藥學上可接受之賦形劑:(a)至少一種磷脂;(b)至少一種針對該至少一種磷脂之增溶劑,其選自由二元醇、甘油酯及其混合物組成之群;(c)至少一種非磷脂界面活性劑;及(d)至少一種含硫抗氧化劑。該膠囊適用於治療特徵為一或多種抗細胞凋亡Bcl-2家族蛋白過度表現之疾病,例如癌症。(無元件符號說明)
