The present invention relates to a method fortreating chronic obstructive pulmonary disease in amammalian subject, which comprises administering aneffective amount of a specific bicyclic compound of formula(I):(see formula I)wherein A1 and A2 are the same or different halogen atomsandB is -COOH, including its pharmaceutically acceptable salts,ethers, esters or amidesand/or a tautomer thereof to a subject in need thereof.
