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COMPOSITIONS OF PARTICULATE COFORMULATION
专利权人:
NEKTAR THERAPEUTICS
发明人:
Mazen H. HANNA,Peter YORK
申请号:
US14841325
公开号:
US20150366241A1
申请日:
2015.08.31
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Embodiments of the invention provide a composition of a particulate coformulation which includes particles containing an active substance and an additive, wherein each particle contains a relative additive concentration increasing radially outwards from a particle center to a particle surface along a finite gradient. In one example, the particle surface is an additive-rich surface without a distinct physical boundary between the particle center and the particle surface. The relative additive concentration may have a continuous rate of change across the finite gradient. In some examples, an active substance:additive ratio of the particle surface is sufficiently low to form a protective surface layer around the active substance. Generally, the particle surface is free of the active substance.
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