Horst A. von Recum,ThimmaReddy Thatiparti,Julius N. Korley,Travis Sill,Iryna Makovey
申请号：
US14451527
公开号：
US20150010608A1
申请日:
2014.08.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent.
