Ke Jian Jim Liu,Laurie Hudson,Karen Cooper,Xixi Zhou
申请号：
US14776929
公开号：
US20160184356A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In one embodiment, the invention provides a method of treating a subject who suffers from a cancer (particularly a chemotherapeutic or radiotherapeutic-resistant cancer) or from an inflammatory disorder, the method comprising co-administering to the subject a pharmaceutically-effective amount of: (a) one or more elements or compounds selected from the group consisting of arsenic, an arsenite and arsenic trioxide (ATO) and optionally (b) at least one anticancer agent (preferably a DNA damaging agent) and/or (c) at least one or more Poly(ADP-ribose) polymerase (PARP) inhibitors other than arsenic, an arsenite and arsenic trioxide (ATO). In preferred embodiments, the arsenic for the treatment of cancer, arsenite and ATO serve as radio sensitizers for concomitant radiotherapy as well as PARP inhibitors. Methods for treating inflammatory disease are also disclosed. Related pharmaceutical formulations are also provided.
