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Inhibiting Senescent Processes in Beta Cells for the Prevention of Type 1 Diabetes
专利权人:
The Regents of the University of California
发明人:
Anil Bhushan
申请号:
US16611158
公开号:
US20200078376A1
申请日:
2018.05.04
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The inventor of the present disclosure has advantageously elucidated the role of senescent processes in the development of Type 1 diabetes. Genotoxic stress responses, senescence, and acquisition of a SASP condition in beta cells are drivers that progress at-risk individuals to overt Type 1 diabetes. The administration of senolytic agents to at risk individuals selectively removes senescent cells and relieves beta cells from the factors which drive the development of overt Type 1 diabetes. Accordingly, Type 1 diabetes can be prevented in at-risk individuals by the administration of senolytic compositions. Additionally, given the major role of SASP in the development of Type 1 diabetes, the inhibition of SASP factors may be used to prevent Type 1 diabetes.
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中国工程科技知识中心
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