A method for performing a hybrid laparoscopic-endoscopic procedure is achieved by inserting a medical instrument laparoscopically through an abdominal wall and into a gastric cavity, inserting an overtube and endoscope transorally into the gastric cavity to provide an access path to the gastric cavity, passing an end effector transorally to the surgical site translumenally within the endoscope, and attaching the end effector to a distal end of the medical instrument while the instrument is positioned within the gastric cavity.
