JIANGQIONG ZHAO,MATTHEW MANGZHU ZHAO,QUN LI,WEIFENG HU,XIAOGEN YANG
申请号：
BR112013011015
公开号：
BR112013011015A2
申请日:
2011.11.03
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
solid forms of -2-amino-3- (4- (2-amino-6 - ((r) -1- (4-chloro-2- (3-methyl-1h-pyrazol-1-yl) acid) ) phenyl) -2,2,2-trifluoroethoxy) pyrimidin-4-yl) phenyl) propanoic acid. The present invention relates to the solid forms of acid. Solid forms of (s) -2-amino-3- (4- (2-amino-6 - ((r) -1- (4-chloro-2-) ( 3-methyl-1H-pyrazol-1-yl) phenyl) -2,2,2-trifluoroethoxy) pyrimidin-4-yl) phenyl) propanoic acid and salts thereof as described. Pharmaceutical dosage forms and methods of their use are also described.formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-cloro-2-(3-metil-1h-pirazol-1-il)fenil)-2,2,2-trifluoroetóxi)pirimidin-4-il)fenil)propanoico. a presente invenção refere-se às formas sólidas de ácido formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-cloro-2-(3-metil-1h-pirazol-1-il)fenil)-2,2,2-trifluoroetóxi)pirimidin-4-il)fenil)propanoico e sais do mesmo que são descritos. formas de dosagem farmacêuticas e métodos de seu uso são também descritos.
