The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5,R6and R7are as described herein.本發明提供式I或IA化合物 或其醫藥上可接受之鹽、異構體、互變異構體或混合物,其中s、t、m、n、R1、R2、R3、R4、R5、R6及R7係如本文中所述。無