The present invention provides a method for preparing a Cordyceps cicadae mycelium composition, comprising the steps of: preparing a Cordyceps cicadae species； inoculating the species into a plate containing a medium and growing into mycelium； cutting the mycelium and then inoculating in a culture solution to culture and obtain a mycelium solution； pouring the mycelium solution into a fermentation tank containing fermentation broth to obtain the mycelium fermentation culture solution； separating the mycelium from the mycelium fermentation culture medium, and after the mycelium is frozen and dried, grinding the mycelium into powder to obtain the Cordyceps cicadae mycelium composition. The present invention also provides an application of using the Cordyceps cicadae mycelium composition to prepare a medicament for the prophylaxis or treatment of nephropathy, wherein the medicament containing cicada mycelium composition and a pharmaceutically acceptable carrier thereof, which is effective for the prophylaxis or treatment of nephropathy.本發明係關於一種具降低因藥物引起腎臟內質網壓力產生腎毒性之蟬花菌絲體組合物的製備方法，其包含齊備一蟬花菌種，接種於培養液中培養獲得菌絲溶液；以發酵槽，於溫度介於25℃至35℃及酸鹼值介於4.5至5.5條件下培養3至5天獲得菌絲發酵培養液；菌絲發酵培養液分離菌絲體並冷凍乾燥後磨成粉狀，即為蟬花菌絲體組合物。另提供一種蟬花菌絲體組合物用於製備預防或治療腎病變的醫藥品的用途，其中醫藥品含有蟬花菌絲體組合物以及其藥學上可接受的載劑，可有效預防或治療腎病變。
