Compression sensing device (1) for measuring an isometric thumb compression force applied by a thumb of a conscious or unconscious patient comprising a handle (3) to be gripped by a hand of the patient, a force sensor (31), and a thumb support (2) mounted at a first end of the handle, for receiving a thumb of the hand of the patient in zero preload conditions and adapted to transmit compression force of the thumb to the force sensor, characterized in that it further comprises a protective shield (4) attached to the handle and at least partially surrounding the thumb support so as to protect it from any external artefactual compression.