Systems and methods for analyzing and/or using information collected from a plurality of users in conjunction with the use of delivery devices for active agents are described. In some embodiments, the delivery device comprises an inhaler device. In some embodiments, the information collecting comprises "crowd sourcing", including collection of inputs from any one or more of a potentially wide variety of user-side data sources. In some embodiments, input collected from a plurality of users in a user population is used to adjust one or regimens for delivery of active agents to individual users. Optionally, regimen effect information comprising reports and/or pharmaceutical effect predictions is provided to individual users based on inputs collected from a plurality of users.