Stephen Warren Hunt, III,Julia Christine Owens,William E. Rainey, JR.,Christopher R. LaPensee,Gary D. Hammer
申请号：
US14498849
公开号：
US20150087649A1
申请日:
2014.09.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods and agents are provided for treatment of disorders associated with aberrant adrenocortical cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC) and/or Cushings syndrome. Such methods involve administration of an agent which exhibits an IC50 value against huACAT1 of less than 10 μM, and one or more further characteristics including effects on adrenocortical cells, disruption of cholesterol homeostasis, reduction in steroid biosynthesis, reduction of mitochondrial function, and/or preferential binding to by low-density lipoprotein (LDL).
