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3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
AISSAOUI HAMED,FRETZ HEINZ,HAZEMANN JULIEN,RICHARD-BILDSTEIN SYLVIA,SIEGRIST ROMAIN
申请号:
NZ60310811
公开号:
NZ603108A
申请日:
2011.03.21
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed herein are 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R1, R2 and R3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. In one embodiment the compound is (3S)-2-(6-fluoro-3-((5-fluoropyrimidin-2-yl)amino)-3,4-dihydro-1H-carbazol-9-(2H)-yl) acetic acid.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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