Peter Ellmark,Christina Furebring,Per Norlen,Eva Dahlen,Sara Fritzell,Niina Veitonmaki,Laura Von Schantz
申请号:
US15567163
公开号:
US20180118841A1
申请日:
2016.05.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides bispecific polypeptides, such as bispecific antibodies, comprising a first binding domain capable of specifically binding to a first T cell target, and a second binding domain capable of specifically binding to a second T cell target, wherein the first and second T cell targets are different targets. The invention further provides compositions of said bispecific polypeptides, as well as methods and uses of the same. The first and/or second T cell target may be selected from the group consisting of OX40, CTLA-4, CD137, CD27, GITR and CD28.