"method for producing methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate and its purification for use therof as pharmaceutical substance"
FRANZ JOSEF MAIS,JOACHIM REHSE,WINFRIED JOENTGEN,KONRAD SIEGEL
申请号：
IN4634/DELNP/2012
公开号：
IN2012DN04634A
申请日:
2012.05.25
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a process for preparing methyl {4,6-diamino-2-[l-(2-fluorobenzyl)-lH-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[l-(2-fluorobenzyl)-lH-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
