THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETHEAR DUBLIN;THE UNIVERSITY OF QUEENSLAND
发明人:
O'NEILL, LUKE,COLL, REBECCA,COOPER, MATTHEW,ROBERTSON, AVRIL,SCHRODER, KATE,MACLEOD, ANGUS MURRAY,MILLER, DAVID JOHN
申请号：
CA3059458
公开号：
CA3059458A1
申请日:
2017.05.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula (I): wherein Q is O or S； R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted； X is any group comprising a carbonyl group； and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.
