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SOLID PREPARATION
专利权人:
Takeda Pharmaceutical Company Limited
发明人:
Ikuro YAMANE,Yukihiro NOMURA,Yutaka NISHIMOTO,Wataru HOSHINA
申请号:
US16432091
公开号:
US20200000730A1
申请日:
2019.06.05
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′;-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.
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