AMORPHOUS SOLID FORM OF A BET PROTEIN INHIBITOR

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专利权人:

发明人:

CHEN, SHILI,陈世黎,陳世黎,FRIETZE, WILLIAM,弗列兹 威廉,弗列茲 威廉,JIA, ZHONGJIANG,贾 忠将,賈 忠將,LIU, PINGLI,刘 平里,劉 平里,ZHOU, JIACHENG,周 家谦,周 家謙

申请号：

TW105135165

公开号：

TW201722966A

申请日:

2016.10.28

申请国别(地区):

TW

年份:

2017

代理人:

摘要：

The present invention relates to an amorphous solid form of (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, and processes for its preparation, which is an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and is useful in the treatment of various diseases such as cancer.本發明係關於(4S)-7-(3,5-二甲基異唑-4-基)-4-吡啶-2-基-4,5-二氫咪唑并[1,5,4-de][1,4]苯并-2(1H)-酮之非晶固體形式及其製備程序,其係諸如BRD2、BRD3、BRD4、及BRD-t之BET蛋白質之抑制劑,並且適用於治療各種疾病諸如癌症。

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