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DIAGNOSIS AND TREATMENT OF MALIGNANT TUMORS OF THE PANCREAS, OVARIES AND OTHER MALIGNANT TUMORS
专利权人:
ИНК. (US);СИЭТЛ ДЖЕНЕТИКС
发明人:
РАЙАН Морин (US),СМИТ Мария Лия (US)
申请号:
RU2010145942/15
公开号:
RU2010145942A
申请日:
2009.04.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An antibody that specifically binds to denatured CD70 on a fixed line of SK-OV-3 or pancreatic cancer pancreatic cancer cells PANC-1 compared to binding to native CD70. ! 2. The antibody according to claim 1, which is a chimeric or humanized antibody. ! 3. The antibody according to claim 1, which binds to denatured CD70 on formalin-fixed paraffin-embedded cells or tissues with specific binding that is the same or better than that of the SG-21.1C1 antibody that is produced by the hybridoma deposited in ATCC and with Assigned Inventory No. PTA-8733, or antibody SG-21.5D12, which produces a hybridoma deposited in ATCC and with designated inventory No. PTA-8734. ! 4. The antibody according to claim 1, which competes for specific binding to denatured CD70 with the SG-21.1C1 antibody, which produces a hybridoma deposited in ATCC and with designated inventory No. PTA-8733, or with antibody SG-21.5D12, which produces a hybridoma deposited in ATCC and with designated inventory No. PTA-8734. ! 5. The antibody according to claim 4, which is an antibody SG-21.1C1, which produces a hybridoma deposited in ATCC and with designated inventory No. PTA-8733 or antibody SG-21.5D12, which produces a hybridoma deposited in ATCC and with designated inventory No. PTA-8734. ! 6. The antibody according to claim 4, containing the variable region of the heavy chain, which is at least 90% identical to the sequence of the variable region of the heavy chain of the antibody SG-21.1C1, and the variable region of the light chain, which is at least 90% identical to the sequence of the variable region light chain antibodies SG-21.1C1. ! 7. The antibody according to claim 4, containing a variable region1. Антитело, которое специфически связывается с денатурированным CD70 на фиксированной линии клеток злокачественной опухоли яичников SK-OV-3 или поджелудочной железы PANC-1 по сравнению со связыванием с нативным CD70. ! 2. Антитело по п.1, которое представляет собой химерное или гуманизированное анти
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