XIONG YIFENG,GROTTICK ANDREW J.,KORMAN HENRY,LEHMANN JUERG,REN ALBERT S.,SEMPLE GRAEME,BAGNOL DIDIER JC
申请号：
CL2017002738
公开号：
CL2017002738A1
申请日:
2017.10.30
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
<； p >； The present Invention relates to compounds of the formula (a), and the pharmaceutical compositions thereof that modulate the activity of GPR52.The compounds and Pharmaceutical compositions of the present Invention of the same are directed to methods useful in the treatment of a disorder mediated by GPR52 (e.g.Huntington's disease, Schizophrenia, bipolar disorder, disorder of attention deficit hyperactivity disorder (ADHD).Or Tourette Syndrome)； a Movement Disorder or extrapyramidal disorder: a motor； a hipercin u00c9tico Movement Disorder； a condition psic u00d3tico； catatonia； a State of disorder u00c1nimOr depresvo； a disorder, an Anxiety Disorder, obsessive compulsive disorder (OCD)； Autism Spectrum Disorder； a related disorder (For example, prolactinHyperprolactinemia)； a neurocognitive disorder； a condition related to the stressor (e.g., or trauma, post-traumatic Stress Disorder (PTSD), conduct disorder,Impulse control or disruptive: a disorder of the Sleep Wake Cycle.A substance related disorder； an addictive disorder； Behavior disorder； hipofrontalidad； an Abnormality in the mesolimbic Pathway tuberoinfundibular,.Mesocortical, or nigroestriada； Lower activity in the striatum； cortical DISFUNCI u00d3N； DISFUNCI u00d3N neurocognitive and conditions related to the same. <； / p >；Compuestos derivados de 1-heteroarl-indolin-4-carboxamida, moduladores de GPR52； composición farmacéutica； útiles para el tratamiento o prevención de un trastorno de movimiento o extrapiramidal, o un trastorno psicótico,un trastorno del estado de ánimo, o un trastorno bipolar en un individuo, entre otros
