The present invention provides a combination drug of a sustained-release preparation for injection which is excellent in the prevention and / or treatment effect of polycystic kidney. Specifically, it relates to a prophylactic and / or therapeutic agent for polycystic kidney characterized by being a sustained-release preparation for injection containing particles containing tolvaptan or a prodrug thereof and a somatostatin analog, and a drug To a method for prevention and / or treatment of sexual cystic kidney disease.本発明は、多発性嚢胞腎の予防及び/又は治療効果に優れた注射用持効性製剤の組合せ医薬を提供する。具体的には、トルバプタン又はそのプロドラッグを含有する粒子及びソマトスタチンアナログを含む注射用持効性製剤であることを特徴とする多発性嚢胞腎の予防及び/又は治療薬、当該薬を用いた多発性嚢胞腎の予防及び/又は治療方法に関する。
