RATTEL, BENNO,FRIEDRICH, MATTHIAS,KUFER, PETER,HOFFMANN, PATRICK,RAUM, TOBIAS,MUNZ, MARKUS,HERRMANN, INES,LUTTERBUESE, RALF,NAHRWOLD, ELISABETH
申请号：
CA2956471
公开号：
CA2956471A1
申请日:
2015.07.31
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
