A. pyrazolpyridin and urea derivatives containing a phenyl porcion substitute were substituted by a group containing so832222 as the binding agent of vanilloide receptor；
ROBERT DR. FRANK,THOMAS DR. CHRISTOPH,NILS DR. DAMANN,BERNHARD DR. LESCH,GREGOR DR. BAHRENBERG,DEREK JOHN DR. SAUNDERS,HANNELORE STOCKHAUSEN,YONG KIM,MYEONG SOO - KIM,JEEWOO SEOP - PROF. DR. LEE
申请号：
ARP120104205
公开号：
AR088799A1
申请日:
2012.11.08
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds for use in the treatment and prophylaxis of diseases and / or Pain and / or additional disorders.Claim 1: a compound of General formula (1), in which r u00b9 u2070 u00b9, r u00b9 u2070 u00b2 and r u00b9 u2070 u00b3 are, independently of one another, selected from the group consisting of H, F, CL, BR, cfh u2082, cf u2082h, cf u2083, CN, ch u2082 ch u2082ch u2082 - - Oh, Oh, ch u2082 - och u2083, ch u2082ch u2082 - och u2083 ocfh u2082 ocf u2082h ocf u2083,,, Oh, nh u2082, a c u2081 u208b u2084 alkyl, alkyl or - NH - c u2081 u208b u2084 c u2081 u208b u2084, alkyl (alkyl, and N u2082, c u2081 u208b u2084)Where the alkyl c u2081 u208b u2084 is not replaced in each case； R u00b2 cf u2083 represents a non substituted alkyl, cycloalkyl or an c u2081 u208b u2084 c u2083 u208b u2086 not replaced； r u2077 and r u2079 are, independently of one another, selected from the group consisting of H, F, CL, BR, cfh u2082, cf u2082h, cf u2083, CN, o Ocf u2083, a c u2081 u208b u2084 alkyl and o-alkyl c u2081 u208b u2084, where in each case the rent c u2081 u208b u2084 is not replaced, denoted n,CH or C (ch u2083)； t is 0, 1 or 2； r u00b9 u2070 u2078 c u2081 u208b u2084 represents alkyl, which is not replaced or mono -, di - or trisustituido with 1, 2 or 3 substituents selected from the group consisting of F, CL, BR, I, or och u2083 = and, optionally in the form of a a single stereoisomer or Mix D E stereoisomers in the form of compound and / or A physiologically acceptable Salt thereof.Compuestos para usarse en el tratamiento y/o profilaxis del dolor y enfermedades y/o trastornos adicionales. Reivindicación 1: Un compuesto de fórmula general (1), en la cual R¹⁰¹, R¹⁰² y R¹⁰³ son, independientemente uno del otro, seleccionados del grupo que consiste de H, F, Cl, Br, CFH₂, CF₂H, CF₃, CN, CH₂-OH, CH₂CH₂-OH, CH₂-OCH₃, CH₂CH₂-OCH₃, OCFH₂, OCF₂H, OCF₃, OH, NH₂, un alquilo C₁₋₄, un alquilo O-C₁₋₄, un alquilo NH-C₁₋₄, y un N(alquil C₁₋₄)₂, donde el alquilo C₁₋₄ está en cada caso n
