Provided herein are cell penetrating conjugates. The conjugates include a non cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non covalent linker including abiotin binding domain and a biotin domain wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non cell penetrating protein. Also provided are compositions and kits comprising the conjugates.
