A system and method for controlling noise produced by an air handling system, for example, is provided. The system includes a source microphone to collect sound measurements from the air handling system and a processor to define a cancellation signal that at least partially cancels out the sound measurements. The system also includes a speaker to generate the cancellation signal. The sound measurements are at least partially canceled out within a region of cancellation. Accordingly, the system further includes a response microphone to collect response sound measurements at the region of cancellation. The processor tunes the cancellation signal based on the response sound measurements.
