Bruce Allan Hay,Brian Christopher Bales,Michael Todd Luttrell,Binil Itty Ipe Kandapallil
申请号：
US12968577
公开号：
US08895068B2
申请日:
2010.12.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
