Patrick SOON-SHIONG,Kayvan NIAZI,Shahrooz RABIZADEH
申请号：
MX2018011306
公开号：
MX2018011306A
申请日:
2017.03.20
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Recombinant viruses and viral nucleic acids are contemplated that provide to the infected cell various regulatory molecules that stimulate T-cell and NK-cell activity and that suppress inhibition of T-cell and NK-cell activity. Most preferably, the virus and viral nucleic acid will further include a human cancer-associated sequence, and especially a sequence that encodes a plurality of cancer associated antigens, cancer specific antigens, and/or patient and tumor specific neoantigens. Especially preferred regulatory molecules include CD80 (B7.1), CD86 (B7.2), CD54 (ICAM-1/BB2), CD11 (LFA-1), and an inhibitor of CTLA-4.Los virus recombinantes y acidos nucleicos virales se contemplan que proporcionan a la celula infectada varias moleculas reguladoras que estimulan la actividad de la celula T y celula NK y que suprime la inhibicion de la actividad de la celula T y celula NK. Mas preferiblemente, el virus y acido nucleico viral incluira ademas una secuencia asociada al cancer humano, y especialmente una secuencia que codifica una pluralidad de antigenos asociados al cancer, antigenos especificos al cancer, y/o neoantigenos especificos al tumor o al paciente. Especialmente las moléculas reguladoras especificas incluyen CD80 (B7.1), CD86 (B7.2), CD54 (ICAM-1/BB2), CD11 (LFA-1), y un inhibidor de CTLA-4.
