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CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION
专利权人:
bioMmune Technologies Inc.
发明人:
Wilfred Jefferies,Reinhard Gabathuler,Raymond Andersen,Lilian Nohara,David Williams
申请号:
US15415291
公开号:
US20170319508A1
申请日:
2017.01.25
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Provided are methods of using curcuphenol compounds to increase expression of major histocompatibility complex class I (MHC-I) antigen in cells, particularly on the surface of diseased cells such as cancer cells, and thereby increase the immunogenicity of the cells. Also provided are pharmaceutical compositions that comprise curcuphenol compounds and methods of use thereof, for instance, to treat various cancers, alone or in combination with other therapies.
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