THE PRESENT INVENTION RELATES TO THE ADMINISTRATION OF COMPOSITIONS COMPRISING AN ANTIESTROGEN, PREFERABLY TRANS-CLOMIPHENE, FOR TREATING METABOLIC SYNDROME IN A SUBJECT. THE INVENTION IS ALSO DIRECTED TO METHODS FOR REDUCING FASTING GLUCOSE LEVELS IN A SUBJECT BY ADMINISTERING A COMPOSITION COMPRISING AN ANTIESTROGEN, PREFERABLY TRANS-CLOMIPHENE.