PARK JOHN E.,DORNER-CIOSSEK CORNELIA,HOERER STEFAN,KUSSMAUL LOTHAR,LENTER MARTIN,ZIMMERMANN KATHARINA,BESTE GERALD,LAEREMANS TOON,MERCHIERS PASCAL,VERCAMMEN JO
申请号：
NZ60111711
公开号：
NZ601117A
申请日:
2011.03.02
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Discloses a polypeptide (antibody or VHH) which binds to two different epitopes on a protein. The peptide comprises a first single variable domain (CDR(1)) and a second variable domain (CDR(2)) which are optionally linked by a linker region. The single variable domain regions comprise the following CDR regions. CDR(1)1: TDTMG CDR(1)2: AVTWNSGRINYADSVKG CDR(1)3: HRFVVGGNRVEDWRY CDR(2)1: NYNMG CDR(2)2: AVSRSGVSTYYADSVKG CDR(2)3: AYRGTAINVRRSYSS Further disclosed is the use of the polypeptide in the manufacture of a medicament for the treatment of neurodegenerative diseases or disorders, such as Alzheimer&rsquo；s or dementia.
