INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Jin HAN,Seung Hun JEONG,In-Sung SONG,Hyoung Kyu KIM,Nari KIM,Larisa K. SHUBINA,Tatyana N. MAKARIEVA,Valentin A. STONIK,Dmitry V. YASHUNSKY,Nikolay E. NIFANTIEV
申请号：
US16327330
公开号：
US20190218206A1
申请日:
2017.05.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to novel pyridine nucleoside compounds, Neopetroside A (NPS A) and Neopetroside B (NPS B) obtained by fractionating an extract of Neopetrosia sp. which is a marine sponge, with ethanol, into n-butanol (n-BuOH). When the NPS A was treated with myocardial cells, it activates oxidative phosphorylation, basal and mitochondrial respiration induced by ATP and ATP synthesis, and stimulates the glycolysis activity and when the NPS A was treated with an ischemic reperfusion injury model, the left ventricular pressure injured by ischemic reperfusion was recovered and the size of myocardial injury site was significantly reduced and as a result, can be provided as the pharmaceutical composition for preventing or treating ischemic heart disease or the health functional food for preventing or improving the same.
