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Bone morphogenetic protein 2 (BMP2 ) variants with reduced BMP antagonist sensitivity
专利权人:
Haase Investments UG
发明人:
Seemann, Petra,Mundlos, Stefan,Reissner, Carsten,Duda, Georg,Zimmer, Julia
申请号:
AU2010223268
公开号:
AU2010223268B2
申请日:
2010.03.11
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
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来源网址:
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