A portable handheld pressure support system configured to provide rapid recovery from dyspnea of a subject is provided. The pressure support system is configured to be small and lightweight so that the subject carries the system and use the system as needed without requiring a device to be worn on the face. The system includes one or more of a pressure generator, a subject interface, a medicament inlet port, one or more sensors, one or more valves, one or more processors, a user interface, electronic storage, a portable power source, a housing, a handle, and/or other components.
