THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES;ADMUNE THERAPEUTICS LLC
发明人:
VOURNAKIS JOHN N.,FELBER BARBARA K.,FINKIELSZTTEIN SERGIO,PAVLAKIS GEORGE N.
申请号：
NZ63079013
公开号：
NZ630790A
申请日:
2013.10.23
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Discloses use of an interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra) complex in the preparation of a medicament for either enhancing IL-15-mediated immune function or for treating/managing cancer in a subject in need thereof, comprising administering the IL-15/IL-15Ra complex to the subject using cyclical administration regimen, wherein the cyclical administration regimen comprises: (a) administering subcutaneously to the subject a dose of 0.1 to 10 &mu；g/kg of the IL-15/IL-15Ra complex every 1, 2 or 3 days over a first period of 1 week to 3 weeks； and (b) after a second period of 1 week to 2 months in which no IL-15/IL-15Ra complex is administered to the subject, administering subcutaneously to the subject a dose of 0.1 to 10 &mu；g/kg of the IL-15/IL-15Ra complex every 1, 2 or 3 days over a third period of 1 week to 3 weeks.
