Sung-Ho Ryu,Pann-Ghill Suh,Sang-Hoon Ha,Mi-Nam Lee,Hyun-Ju Lee,Il-Shin Kim,Do-Hyung Kim,Tae-Hoon Lee
申请号：
US12374239
公开号：
US08168177B2
申请日:
2007.08.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
